MARC details
| 000 -LEADER |
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| fixed length control field |
04227nam a22004337 4500 |
| 001 - CONTROL NUMBER |
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| control field |
37041 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MED |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250917091742.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS |
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| fixed length control field |
m o d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr cnu|||||||| |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
230715s2023 cau o ||| 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9780443154621 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
0443154627 |
| 035 ## - SYSTEM CONTROL NUMBER |
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| System control number |
(OCoLC)1390558054 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EBLCP |
| Language of cataloging |
eng |
| Transcribing agency |
EBLCP |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
541 |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Koltai, Tomas. |
| 245 10 - TITLE STATEMENT |
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| Title |
PH Deregulation As the Eleventh Hallmark of Cancer. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
San Diego : |
| Name of publisher, distributor, etc. |
Elsevier Science & Technology, |
| Date of publication, distribution, etc. |
2023. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
1 online resource (192 p.) |
| 500 ## - GENERAL NOTE |
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| General note |
Description based upon print version of record. |
| 500 ## - GENERAL NOTE |
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| General note |
Lactate tracers for patient treatment monitoring |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Intro -- pH Deregulation as the Eleventh Hallmark of Cancer -- Copyright -- Dedication -- Contents -- Acknowledgment -- Introductory words -- Chapter 1: pH Regulation and metabolism: Basic concepts -- pH regulation -- Concentration of protons ([H+]) and pH -- Some basic definitions -- pH homeostasis -- What is the need for these different pH compartments? -- Buffers -- pH and enzymatic activity -- Transport of substances and ions in and out of cells -- The proton extruders -- Metabolism -- Antimetabolite -- Cell respiration and metabolism |
| 505 8# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
How does CO2 play an important role in acid-base balance? -- In summary [25-28] -- References -- Chapter 2: The pH gradient in cancer: pH deregulation -- Historical background -- Main participants of the pHtome -- When does the pH inversion start? -- How does the pHtome work -- How do cancer cells survive in the acidic microenvironment? -- Where to search for adaptation? -- Apoptosis -- Plasma membrane proteins -- Plasma membrane potential (Vm) -- Mannose glycosylation -- Exosomes -- Lipid metabolism -- Extracellular acidity: The origins -- Extracellular acidity: The consequences |
| 505 8# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Intracellular alkalinity -- Metabolic reprogramming: A major contributor to pH deregulation -- The origin of the two main ECM acidifiers -- Advantages of the metabolic shift -- Is there an objective in metabolic switch? -- The role of hypoxia -- What is the importance of the pH gradient inversion? -- Why is it important to recognize pH deregulation as a hallmark of cancer? -- Conclusions -- References -- Chapter 3: The pHtome -- Introduction -- Why are there so many participants in the pHtome? -- Can the pHtome be inhibited? -- References -- Chapter 3.1: Na+/H+ exchangers (NHEs) -- Introduction |
| 505 8# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Tissue and subcellular distribution -- NHE's in breast and prostate cancer -- Summary -- References -- Chapter 3.2: Voltage gated sodium channels (VGSCs) -- Structure (Figs. 1 and 2) -- VGSCs in cancer -- NaV1.5 and breast cancer -- Clinical implications -- Discussion -- Other possible combinations -- References -- Chapter 3.3: Carbonic anhydrases (CAs) -- Introduction -- Structure -- Intracellular carbonic anhydrase II (CA II) -- CA II in tumors -- Inhibiting CAs -- Conclusions -- References -- Chapter 3.4: The sodium bicarbonate cotransporter (NBC) family -- General overview |
| 505 8# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
NBC protein structure, isoforms and tissue distribution -- Nomenclature -- NBC in normal physiology: Role and regulation -- NBC in disease: Role in the cancer pHtome -- NBC expression in malignancy and clinical significance -- Targeting NBC for cancer treatment -- Conclusions -- References -- Chapter 3.5: Monocarboxylate transporters (MCTs) and lactate -- Lactic acid or lactate? -- Role of lactate in cancer -- Lactate as oncometabolite -- Lactate as a signaling molecule -- MCT structure, function and role in cancer -- MCTs as targets for cancer therapy |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Fliegel, Larry. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Reshkin, Stephan J. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Baltazar, Fatima. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Cardone, Rosa Angela. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Alfarouk, Khalid Omer. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Afonso, Julieta. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
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| Relationship information |
Print version: |
| Main entry heading |
Koltai, Tomas |
| Title |
PH Deregulation As the Eleventh Hallmark of Cancer |
| Place, publisher, and date of publication |
San Diego : Elsevier Science & Technology,c2023 |
| International Standard Book Number |
9780443154614 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Public note |
Click here to view book |
| Uniform Resource Identifier |
<a href="https://public.ebookcentral.proquest.com/choice/PublicFullRecord.aspx?p=7267277">https://public.ebookcentral.proquest.com/choice/PublicFullRecord.aspx?p=7267277</a> |
| 936 ## - OCLC/CONSER MISCELLANEOUS DATA (OCLC); PIECE USED FOR CATALOGING (pre-AACR2) (RLIN) |
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| OCLC control number(s) of parallel record(s) (OCLC); Piece used for cataloging, PUC (RLIN) |
|
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Library of Congress Classification |
| Koha item type |
كتاب |
| Suppress in OPAC |
No |
| 948 ## - LOCAL PROCESSING INFORMATION (OCLC); SERIES PART DESIGNATOR (RLIN) |
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| h (OCLC) |
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