Homologation reactions : reagents, applications, and mechanisms /
edited by Vittorio Pace.
- volume 1(xix,466 pages) : illustrations (some color) ; 25 cm
Provides a unique summary of homologation strategies in organic synthesis Homologation Reactions presents different concepts underpinning the use of homologating reagents as well as their applications in organic synthesis. It covers in-depth discussions on the rationales governing this kind of transformations with a strong emphasis on mechanistic elements modulating critical aspects (e.g. selectivity) of the processes. In addition, this two-volume work features: * Metal carbenoids, ylides, and diazo reagents * Homologating agents working under nucleophilic, electrophilic, and radical regime * Homologations realized on boron-containing or carbon-centered linchpins * Use of highly sensitive fluorinated homologating agents * Progressive homologations and the concept of assembly line synthesis * Homologation processes followed by rearrangement cascades * Construction of cyclic motifs and ring-expansion * Homologation reactions with carbon monoxide and carbon dioxide * New and/or challenging directions to expect in the future Written by an international team of leaders in the field, the book is a useful guide for designing effective transformations by using homologation reactions. It is a must-read for every synthetic chemist in academia and industry!