TY  - BOOK
AU  - 
AU  - Cromm,Philipp
TI  - Inducing targeted protein degradation =: from chemical biology to drug discovery and clinical applications 
SN  - 9783527350131
AV  - RM301.25 .I53 2023
U1  - 574.1 23
PY  - 2023///
CY  - Weinheim
PB  - Wiley-VCH
KW  - philipp Cromm
KW  - Drug development
KW  - Biochemistry
KW  - Proteolysis
KW  - M�edicaments
KW  - D�eveloppement
KW  - Biochimie
KW  - Prot�eolyse
KW  - biochemistry
KW  - aat
KW  - fast
N1  - chemical and Biology; Includes bibliographical references and index; Targeted Protein Degradation - The Story So Far / Daniel H O Donovan, Laura M Luh, Philipp M Cromm -- Cellular Principles of Targeted Protein Degradation / Jo�ao Diamantino, Doris Hellerschmied -- E3 Ubiquitin Ligases as Molecular Machines and Platforms for Drug Development / Rafael M Ioris, Katherine Ferris, Vincenzo D'Angiolella -- A Structural and Biophysical Perspective of Degrader Activity Through Ternary Complex Formation / Morgan S Gadd, Marine C Aublette -- Computational Modeling of PROTAC Ternary Complexes and Linker Design / Sven A Miller, Grigorii V Andrianov, Victoria Mischley, Khadija A Wharton, Jesse J Chen, John Karanicolas -- Molecular Glue Degraders: From Serendipity to Hunting and Design / Luis Nieto-Barrado, Ana Domostegui, Cristina Mayor-Ruiz -- Targeted Protein Degradation as a Therapeutic Strategy in Neurodegenerative Diseases / Fleur M Ferguson -- Insights and Future Perspectives of Covalent Protein Degraders / Xiaoyu Zhang -- Extending the Degradation Toolkit - mRNA Targeting as an Alternative Means to Affect Protein Levels / Andrei Ursu, Barbara Herdy, Hendrik Osadnik -- The Future of Heterobifunctional Compounds: PROTACs and Beyond / George M Burslem -- Destruction with a Purpose: Targeted Protein Degradation in Drug Discovery / Paola Martinelli, Christiane Kofink, Georg Boeck, Harald Weinstabl, Manfred Koegl -- Taming the Beast: How to Optimize DMPK-PD Properties of Oral Degraders / Caroline Rynn, Arthur Van De Vyver, Antje Walz, Carina Cantrill, Matthias Wittwer -- PROTAC � Protein Degraders: Bridging the Divide from Chemical Biology Tools to Clinical Candidates / Erika MV Araujo, Keith R Hornberger
N2  - Since the breakthrough of the PROTAC technology in 2015, targeted protein degradation has revolutionized drug discovery, enabling pharma companies to develop completely novel therapeutics. Inducing Targeted Protein Degradation is a timely guide to navigating the complexities of the subject and understanding its practical application, with an eye on expanding the druggable space
UR  - http://dx.doi.org/10.1002/9783527836208
ER  -