Phytochemicals as Lead Compounds for New Drug Discovery / edited by Chukwuebuka Egbuna, Shashank Kumar, Jonathan C. Ifemeje, Shahira M. Ezzat, Saravanan Kaliyaperumal.

Part I: Plants as natural sources of drugs -- Chapter 1 -- Plant secondary metabolites as lead compounds for the production of potent drugs / Vijay Kumar Srivastav, Chukwuebuka Egbuna and Meena Tiwari -- Chapter 2 -- Factors affecting the choice for plant-based products in drug discoveries / Godwin Anywar and Jane Namukobe -- Chapter 3 -- Advances in computer-aided drug discovery / Israel Ehizuelen Ebhohimen, Lawrence Edemhanria, Simon Awojide, Ojei Harrison Onyijen, Godwin Anywar -- Chapter 4 -- FDA drug candidacy acceptance criteria and steps: problems and way forward / Shahira M. Ezzat, Mahitab H. El Bishbishy, Angelo Mark P.Walag, Andrew G. Mtewa -- Part II: Biofunctional leads for drug development -- Chapter 5 -- Bioactive lead compounds and molecular targets for the treatment of heart diseases / Shahira M. Ezzat, Maha M. Salama and Mohamed A. Salem -- Chapter 6 -- Natural bioactive lead compounds effective against haematological malignancies / Amelia Maria G�aman, Chukwuebuka Egbuna and Mihnea-Alexandru G�aman -- Chapter 7 -- Adjunct therapeutic potential of phytochemicals against cancer / Vishal Kumar Gupta, Pradip Kumar Jaiswara, Pratishtha Sonker, Shiv Govind Rawat, Ajay Kumar -- Chapter 8 -- Antidiabetic lead compounds and targets for drug development / Genevieve D. Tupas, Maria Catherine B. Otero, Israel Ehizuelen Ebhohimen, Chukwuebuka Egbuna, Maria Aslam -- Chapter 9 -- Antiobesity functional leads and targets for drug development / Gabriel O. Anyanwu, Andreas F. Kolb and Giovanna Bermano -- Chapter 10 -- Phytochemicals as therapeutic interventions in neurodegenerative diseases / Raj V. Kavitha, J.R. Kumar, Chukwuebuka Egbuna, Jonathan C. Ifemeje -- Chapter 11 -- Organosulfur phytochemicals against metabolic and neurodegenerative diseases: benefits and risks / Astha Dwivedi, Sharmistha Singh, Sandeep Kumar, Poonam C. Mittal -- Chapter 12 -- Lead compounds with the potentials for the treatment of chronic liver diseases / Devaraj Ezhilarasan -- Chapter 13 -- Bioactive lead compounds effective against skin diseases / Ujah O. Frederick and Hough A. Samson -- Chapter 14 -- Phytochemicals as emerging therapeutic agents for alopecia treatment / A. Premanand, V. Benedic Ancy, Jaison Jeevanandam, B. Reena Rajkumari, Michael K. Danquah -- Chapter 15 -- Antiviral phytocompounds for drug development: a data mining studies / Saravanan Kaliyaperumal, Karuppannan Periyasamy, Umarani Balakrishnan, Premalatha Palanivel, Chukwuebuka Egbuna -- Chapter 16 -- Shikimic acid as intermediary model for the production of drugs effective against influenza virus / Priyanka Singh, Ena Gupta, Neha Mishra, Pragya Mishra -- Chapter 17 -- Antimicrobial lead compounds from marine plants / Jaya Vikas Kurhekar -- Chapter 18 -- Antibacterial lead compounds and their targets for drug development / Ashutosh Gupta and Abhay K. Pandey -- Chapter 19 -- Awareness and current therapeutic strategies of malaria / Muhammad Akram, Muhammad Riaz, Muhammad Daniyal, Rida Zainab -- Chapter 20 -- Bioactive lead compounds and targets for the development of antimalarial drugs / Prem Prakash Kushwaha, Pothabathula Seshu Vardhan, Priyanka Kumari, Andrew G. Mtewa, Shashank Kumar -- Chapter 21 -- Bioactive lead compounds and molecular targets for the development of anti-inflammatory drugs / Onyeka K. Nwosu, Merve Keskin, HemaLohani, Chukwuebuka Egbuna, S. Zafar Haider -- Chapter 22 -- Functional lead compounds and targets for the development of drugs for the treatment of male infertility / Manisha Pathak, Shrikant Sharma, Prem Prakash Kushwaha, Shashank Kumar -- Chapter 23 -- Prenylated flavonoids as a promising drug discovery candidate: a pharmacological update / Prem Prakash Kushwaha, Sunita Kumari Prajapati, Seshu Vardhan Pothabathula, Atul Kumar Singh, Mohd Shuaib, Karnika Joshi, Shashank Kumar.

Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain.