000			04117cam a2200589 i 4500
001			34846
003			OCoLC
005			20250819142610.0
006			m o d
007			cr |n|||||||||
008			221114s2023 gw a ob 001 0 eng d
020			_a9783527350131 _qelectronic book _qoBook
024	7		_a10.1002/9783527836208 _2doi
029	1		_aAU@ _b000073230554
035			_a(OCoLC)1350708320
040			_aYDX _beng _erda _cمكتبة قسم علوم الحياة
050		4	_aRM301.25 _b.I53 2023
060		4	_aQV 744 _b.I42 2023
082	0	4	_a574.1 _223 _bC;946
100			_qCromm.philipp _eEdited
245	0	0	_aInducing targeted protein degradation = _bfrom chemical biology to drug discovery and clinical applications / _cedited by Philipp Cromm.
264		1	_aWeinheim : _bWiley-VCH, _c2023.
300			_a1 online resource : _billustrations (some color) _c24cm
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
440			_aInducing targeted protein degradation
500			_achemical and Biology
504			_aIncludes bibliographical references and index.
505	0		_aTargeted Protein Degradation - The Story So Far / Daniel H O Donovan, Laura M Luh, Philipp M Cromm -- Cellular Principles of Targeted Protein Degradation / Jo�ao Diamantino, Doris Hellerschmied -- E3 Ubiquitin Ligases as Molecular Machines and Platforms for Drug Development / Rafael M Ioris, Katherine Ferris, Vincenzo D'Angiolella -- A Structural and Biophysical Perspective of Degrader Activity Through Ternary Complex Formation / Morgan S Gadd, Marine C Aublette -- Computational Modeling of PROTAC Ternary Complexes and Linker Design / Sven A Miller, Grigorii V Andrianov, Victoria Mischley, Khadija A Wharton, Jesse J Chen, John Karanicolas -- Molecular Glue Degraders: From Serendipity to Hunting and Design / Luis Nieto-Barrado, Ana Domostegui, Cristina Mayor-Ruiz -- Targeted Protein Degradation as a Therapeutic Strategy in Neurodegenerative Diseases / Fleur M Ferguson -- Insights and Future Perspectives of Covalent Protein Degraders / Xiaoyu Zhang -- Extending the Degradation Toolkit - mRNA Targeting as an Alternative Means to Affect Protein Levels / Andrei Ursu, Barbara Herdy, Hendrik Osadnik -- The Future of Heterobifunctional Compounds: PROTACs and Beyond / George M Burslem -- Destruction with a Purpose: Targeted Protein Degradation in Drug Discovery / Paola Martinelli, Christiane Kofink, Georg Boeck, Harald Weinstabl, Manfred Koegl -- Taming the Beast: How to Optimize DMPK-PD Properties of Oral Degraders / Caroline Rynn, Arthur Van De Vyver, Antje Walz, Carina Cantrill, Matthias Wittwer -- PROTAC � Protein Degraders: Bridging the Divide from Chemical Biology Tools to Clinical Candidates / Erika MV Araujo, Keith R Hornberger.
520			_aSince the breakthrough of the PROTAC technology in 2015, targeted protein degradation has revolutionized drug discovery, enabling pharma companies to develop completely novel therapeutics. Inducing Targeted Protein Degradation is a timely guide to navigating the complexities of the subject and understanding its practical application, with an eye on expanding the druggable space.
588			_aDescription based on online resource; title from digital title page (viewed on December 01, 2022).
600			_aphilipp Cromm
650		0	_aDrug development.
650		0	_aBiochemistry.
650		0	_aProteolysis.
650		2	_aBiochemistry
650		2	_aProteolysis
650		6	_aM�edicaments _xD�eveloppement.
650		6	_aBiochimie.
650		6	_aProt�eolyse.
650		7	_abiochemistry. _2aat
650		7	_aBiochemistry _2fast
650		7	_aDrug development _2fast
650		7	_aProteolysis _2fast
700	1		_aCromm, Philipp, _eeditor.
776	0	8	_cOriginal _z3527350136 _z9783527350131 _w(OCoLC)1240493342
856	4	0	_3John Wiley _uhttp://dx.doi.org/10.1002/9783527836208
910			_aمها ازاد حامد
942			_2ddc _cBK
948			_hNO HOLDINGS IN IQMCL - 230 OTHER HOLDINGS
999			_c34846 _d34846