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020			_a9780443154621
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035			_a(OCoLC)1390558054
040			_aEBLCP _beng _cEBLCP
082	0	4	_a541
100	1		_aKoltai, Tomas.
245	1	0	_aPH Deregulation As the Eleventh Hallmark of Cancer.
260			_aSan Diego : _bElsevier Science & Technology, _c2023.
300			_a1 online resource (192 p.)
500			_aDescription based upon print version of record.
500			_aLactate tracers for patient treatment monitoring
505	0		_aIntro -- pH Deregulation as the Eleventh Hallmark of Cancer -- Copyright -- Dedication -- Contents -- Acknowledgment -- Introductory words -- Chapter 1: pH Regulation and metabolism: Basic concepts -- pH regulation -- Concentration of protons ([H+]) and pH -- Some basic definitions -- pH homeostasis -- What is the need for these different pH compartments? -- Buffers -- pH and enzymatic activity -- Transport of substances and ions in and out of cells -- The proton extruders -- Metabolism -- Antimetabolite -- Cell respiration and metabolism
505	8		_aHow does CO2 play an important role in acid-base balance? -- In summary [25-28] -- References -- Chapter 2: The pH gradient in cancer: pH deregulation -- Historical background -- Main participants of the pHtome -- When does the pH inversion start? -- How does the pHtome work -- How do cancer cells survive in the acidic microenvironment? -- Where to search for adaptation? -- Apoptosis -- Plasma membrane proteins -- Plasma membrane potential (Vm) -- Mannose glycosylation -- Exosomes -- Lipid metabolism -- Extracellular acidity: The origins -- Extracellular acidity: The consequences
505	8		_aIntracellular alkalinity -- Metabolic reprogramming: A major contributor to pH deregulation -- The origin of the two main ECM acidifiers -- Advantages of the metabolic shift -- Is there an objective in metabolic switch? -- The role of hypoxia -- What is the importance of the pH gradient inversion? -- Why is it important to recognize pH deregulation as a hallmark of cancer? -- Conclusions -- References -- Chapter 3: The pHtome -- Introduction -- Why are there so many participants in the pHtome? -- Can the pHtome be inhibited? -- References -- Chapter 3.1: Na+/H+ exchangers (NHEs) -- Introduction
505	8		_aTissue and subcellular distribution -- NHE's in breast and prostate cancer -- Summary -- References -- Chapter 3.2: Voltage gated sodium channels (VGSCs) -- Structure (Figs. 1 and 2) -- VGSCs in cancer -- NaV1.5 and breast cancer -- Clinical implications -- Discussion -- Other possible combinations -- References -- Chapter 3.3: Carbonic anhydrases (CAs) -- Introduction -- Structure -- Intracellular carbonic anhydrase II (CA II) -- CA II in tumors -- Inhibiting CAs -- Conclusions -- References -- Chapter 3.4: The sodium bicarbonate cotransporter (NBC) family -- General overview
505	8		_aNBC protein structure, isoforms and tissue distribution -- Nomenclature -- NBC in normal physiology: Role and regulation -- NBC in disease: Role in the cancer pHtome -- NBC expression in malignancy and clinical significance -- Targeting NBC for cancer treatment -- Conclusions -- References -- Chapter 3.5: Monocarboxylate transporters (MCTs) and lactate -- Lactic acid or lactate? -- Role of lactate in cancer -- Lactate as oncometabolite -- Lactate as a signaling molecule -- MCT structure, function and role in cancer -- MCTs as targets for cancer therapy
700	1		_aFliegel, Larry.
700	1		_aReshkin, Stephan J.
700	1		_aBaltazar, Fatima.
700	1		_aCardone, Rosa Angela.
700	1		_aAlfarouk, Khalid Omer.
700	1		_aAfonso, Julieta.
776	0	8	_iPrint version: _aKoltai, Tomas _tPH Deregulation As the Eleventh Hallmark of Cancer _dSan Diego : Elsevier Science & Technology,c2023 _z9780443154614
856	4	0	_zClick here to view book _uhttps://public.ebookcentral.proquest.com/choice/PublicFullRecord.aspx?p=7267277
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999			_c37041 _d37041